Side Effects After Long Term Usage
(Newest replies first)

After twenty two years on amitrypt 150mg at night for treatment of neuropathic pain I am now suffering from an inability to stabilise my body temperature ? Due to damage done to my hypothalamus by taking this drug I am constantly sweating profusely and going hot then cold no matter what clothes I am wearing or what the weather is like. I recently stopped taking it having been put on other drugs for depression and bitterly regret the years I did spend taking it when the only side effect I was told about was a possibility of an increased appetite and weight gain Please can someone tell me more about the damage to the hyper thalamus and whether it as I fear may be a permanent factor of my very uncomfortable lifestyle

REPLY

REPORT

I have been on ropinirole 1mg tabs. THE SCHEDULE IS 1/2 TAB AFTER LUNCH WITH TWO AT BEDTIME. I'm having the following problems: lack of balance/coordination and serious headaches. I have very serious RESTLESS LEGS. I'm CONCERNED WITH THE MEMOREY LOSS. I NEED ADVICE. I'm 84 years old. {edited for privacy}

REPLY

Was this helpful? 0

Hi Mary,

Based on my research, there are actually government studies which have been done, suggesting that Amitriptyline is responsible for decreased activity of the hypothalamus (which regulates body temperature).

If you run a Google search for "Amitriptyline hypothalamus", you should be able to find some of those articles verifying this. However I haven't seen anything just yet in regards to how long these effects might play out for.

Because you've been taking this medication for so many years, it's likely that your body adapted to having it on a regular basis and has to start learning to function without it. That said, the withdrawal effects from 22 years of use may just end up lasting a lot longer than the typical time frame in which people tend to experience such symptoms.

Have you tried using any natural alternatives such as cayenne pepper, exercise, or even just drinking plenty of alkaline water, to help stabilize your body temp on a daily basis?

REPLY

Was this helpful? 0

My daughter has been on clonidine for approx 10yrs...she is 17 now. Lately she has had several issues with extremely low...

1 REPLY

I take codeine 5mg for pain due to a pinched nerve. If I take 7/day I am pretty much pain controlled and can go about my...

1 REPLY

I have taken Lyrica for over three years for serious Neuropathies (Level 10 pain...unable to leave my home or function a...

16 REPLIES

I have been taking Chantix for 4 days in a row and I feel horrible!!! how soon will this be out of my system?? ## Hello,...

2 REPLIES

ive been on cilift for 5 years and went off about a month ago, for the past week i have not been able to sleep, maybe 3-...

2 REPLIES

Iv took pain for years.now i want quit how long does the side effects last? ## Hello, Dave! How are you? Tapering off of...

6 REPLIES

I will try to make this as short as possible. I have been suffering with Chronic Pain to my right shoulder since 2005. I...

7 REPLIES

iam 25 yrs old,my first baby got miscarried in 5 months an year ago, how to get pregnant for the next baby .as iam takin...

14 REPLIES

I had Harvoni treatment last spring. I am not the same. My nervous system is a wreck. My anxiety problems have increased...

263 REPLIES

What are the long term effects of the brain and mood changes in people taking 30mg of oxycodone for years? Do they act w...

6 REPLIES