How Long Does Linzess Stay In Your System


How long does it take for Linzess to be completely out of your system?

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From what I could gather, Linaclotide (Linzess) doesn't remain in your system very long at all. According to a study on, the parent drug (Linaclotide) completely degrades to its metabolite within 30 minutes, with a first-order half-life of only 3 minutes.

[1] source: PubMed / PMC3638410

That said, my understanding is that Linzess should be completely out of one's system within 1-3 days easy. However there are other important variables outside of the half life that may prolong or otherwise have some sort of impact on the estimated time frame.

Hope this helps!
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How long does it take on average for Linzess to get out of the body?

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Re: Tan (# 2) Expand Referenced Message

I am 115 lbs and I feel the effects of Linzess for at least 2 days. I get bloating and gas. I am now on the 72 MCG dose, but am still feeling after effects.

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Re: David (# 1) Expand Referenced Message

Thank you David. I am very worried. My Grandson has had chronic constipation since birth. Dr's tell us to give him mirilax, did. Didn't do any miracles but helped. Now that he's 16 he refuses to take the powder, it's gritty and he says tastes awful. Anyway, my concern now is for 4-3 days he hasn't went, he's very tired, nauseous, been sent home 2 days in a row this week because of feeling tired and feeling bad and nauseous. So I gave him one 145 mcg Linzess capsule tonight at about 8:59pm. He kept trying go before and no go. So I thought the bottle said, do not give to children under age 6. It did. So I gave him one. Then went to read how long before it may work, and read 'don't give to children under 6 at all, or between 6-18 years of age'. I am now freaking out. Please let me know if you think 1 pill will hurt him. As you can see I can not sleep. Appreciate any advice.

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Re: Kitty (# 4) Expand Referenced Message

I'm very sorry to hear about your grandson. I hope he's gotten around to feeling better since the timing of your post. Unfortunately, since there's no way of knowing ahead of time how anyone will react/respond to pharmaceutical medications, all I can do is encourage him to consult with a doctor when it comes to prescription drugs such as Linzess... However, I don't know if you heard of Essiac tea leaf, but it works miracles for me and my family whenever serious indigestion occurs, so I just thought I'd mention it as another possible avenue of treatment. I'm actually very hesitant to take it unless the problem is severe because it works almost too well. All you need is an 8oz cup full and it seriously cleans you out like nobody's business, LOL! I believe it is readily available at most health food stores as well as Amazon and other internet retailers. Please let me know if I could be of any more assistance in this matter.

Wishing you both good health always!

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I don't know but I had an allergic reaction after the 3rd pill. It started in my mouth, then I broke out and had swelling of the tongue. Couldn't eat for a week.

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I'm having cold like symptoms after taking Linzess, how long will these symptoms continue? They are quite annoying.

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Re: Barbara (# 7) Expand Referenced Message

I am feeling the same way after taking Linzess... I have a headache, dizziness, diarrhea, and am feeling cold.

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Re: Cathy (# 3) Expand Referenced Message

Very dangerous drug. Just got off. I wouldn't be surprised if there's a cover up of this drug.

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How long does it take for Linzess to leave your system?

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Re: Pat (# 8) Expand Referenced Message

Same I took 75mg yesterday and I have a headache stomach pains etc. unfortunately this is the only medication that lets me go. But the side effects I get cold shaky I feel like I’m going to pass out I get extremely dizzy I hope I can find something else that works and doesn’t cause so much discomfort.

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Re: Diane (# 9) Expand Referenced Message

Please, pretty please, explain!

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Re: NinaBaker (# 11) Expand Referenced Message

I've been on linzess for about 3 to 4 weeks now and I've had this happening to me also, so I stopped taking it but I'm still getting the pass out feeling with lightheadedness and dizziness. Was in the ER for it last night. Pretty scary. How long until that went away for you after u quit taking it?

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Re: Jesse (# 13) Expand Referenced Message

I have had heart palpitations for 2months since stopping Linzess. I now see a heart doctor as I can't sleep and have dizzy spells regularly. This medicine is evil and causes this problem in 100% of women, 50% of African Americans and 33% people between 50-59. I fall in all categories and don't know when I will recover.

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I have been off of Linzess now for 3 weeks because of bad rectal bleeding! The effects of this drug still has not gone away (severe gas and bloating with very soft stool oozing -- this has been a mess! Never experienced this before the Linzess! I have now had to start to use the very strong anti-diarrhea to try and stop this mess)!

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I also was on the 72... I only took for a week, my symptoms worsened, and even started with bad headaches. Been off for two days and still have headaches.

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How long does it stay in your system and does it clean out your system?

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How long does it take for linzess to leave your system before beginning another med?

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Re: Kitty (# 4) Expand Referenced Message

Did you ever get resolve for your little man? I received a good quality probiotic and prebiotic that has science to back its efficacy. I am a mother of 4 and would never give advice to others that I do not follow for myself and my family. Please reach out if guys like more information. I hope he’s much better!!

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Re: NinaBaker (# 11) Expand Referenced Message

Drink SMARTWATER at least 2 cups. It has the correct balance of potassium and sodium.

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Lots of different reactions to this here, in my own experience is that it's caused headaches, general sadness and even hyponetramia but once armed with the knowledge of how my body reacts to it I manage to negotiate these things by taking 100mg magnesium at night and then I take 290mcg of Linzess around 7 am next morning with around 250ml of water then drink a couple of cups of sweet (using honey) milky decaffeinated tea which Seems to activate it (I'm not a breakfast person) and put 1 teaspoon of salt in hot water and take sips alongside my tea to replce the sodium I know I'm losing and it usually starts working around 1 hour ir so later lasts around an hour and a half or so then I can get on with my day though I do have to drink more fluids and salt water for an hour or so after. I also eat green veggies every day opting for frozen as its hard to stay sticked up on fresh veg daily due to logistics. Despite this rigmarole I'm usually ready to face the day by lunchtime and then eat and have some normality which I've never had with other meds. It's a strong med I won't deny it but it does work though from the replies in this thread I can see its not for everyone.
One tip for everyone here is for bloating and soreness I take a teaspoon of manuka honey after the effects have worn off and despite the cost its far better and kinder on the gut than any medication I've ever had. I hope this info is useful to at least 1 person, it's a pretty harsh med but can give some normality back once gauged for subjective experience and effects but it does take its toll if you're not cautious while taking it, just drinking lots of fluids isn't enough and dangerous as it will make your sodium, magnesium and potassium drop drastically in a short space of time.

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Re: Kimberly (# 17) Expand Referenced Message

How long does it stay n my system
I feel I've been poisoned

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Re: Diane (# 9) Expand Referenced Message

I agree with you. It's poisoning my body. Severe dehydration and nauseated for days, heart burn, etc. Quit taking it 2 days ago. I was prescribed 12/06/2023. I called CVS and reported Linzess. It has damage people's intestines. Bad reviews. I will call MedWatch and report Linzess.

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Re: Barbara (# 7) Expand Referenced Message

I have been sick 5 days. Server dehydration and nauseated and smells. I quit taking linzess it poison my body. Explorted with my fluids watery came out. I have nothing left. I can bear lying sip water. Need help

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Re: Diane (# 9) Expand Referenced Message

You say this without staying why? Please share what you know and nobody else does?

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Re: Farley (# 36) Expand Referenced Message

I just started Linzess. I learned that depression could be a side effect or diarrhea. I am taking 290mgs, I am clinically depressed. So, search Linzess, you may want to change meds. I've had IBS pain all my life, I took muscle relaxers when the pain was unbearable, not everyday. Your heart is a muscle too, so I did not take it often. As I grew older they didn't work, so now I started Linzess. I think 290mgs is pretty strong. I will probably take it in the AM on an empty stomach and eat within a half hour.

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Re: Barbara (# 15) Expand Referenced Message

Please tell me all this stopped finally. I’m having all these issues now and I’m very sick. Thank you!

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Re: AMTaylor (# 34) Expand Referenced Message

I feel like my actual stomach hurts. I think this medicine makes everything in your digestive system off.

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Re: Farley (# 36) Expand Referenced Message

Yes, I’ve been taking it for a month and I’ve had weird sadness. This drug has made me very ill, and I have had COVID, swine flu and the bird flu and this drug feels worse!

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Re: Kitkat (# 28) Expand Referenced Message

I have been taking 290 mg a day for a month with no bad side effects, but it just isn't working for me. Does help with bowel movement and still have to strain to go.

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