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Comparisim Of Activity Of Nsaid

Updated October 30, 2014
Emmanuel Hokins Says:
Tue, October 28, 2014

Can you give me a comprehensive details comparing the activity/responsiveness of the following NSAID. Aspirin, Aceclofenac, Diclofenac, Lornoxicam,Meloxicam, Piroxicam, Tenoxicam,Ketoprofen,Naproxen, in relationship to their individual Analgesic, Anti-inflammatory and Antipyretic properties.

1 Reply

1
David Says:
Thu, October 30, 2014

Hi Emmanuel,

When it comes to comparing any medication's properties for determining overall efficacy, I think one important thing to take into consideration as well, would be the list of inactive ingredients companies use as binders/fillers in these tablets. Reason I say this is because certain substances they add in there, have been reported to decrease a medication's bioavailability on a noticeable level. And I believe what happens here is that some of these genetically modified binders/fillers are not able to fully metabolize in our body; inevitably blocking the actual active ingredient(s) from being fully released from within.

I don't know if you've heard about the ongoing complaints on here pertaining to Actavis's Norco product, in comparison with the original Watson brand, but this was a similar situation where the same active ingredients were being used, but changes in the inactive ingredients caused Actavis's product to be inferior to Watson's; despite similarities in dosages.

So going back on topic, there's really no way outside of trying each medication for yourself, to know which one's are better or worse for treating your condition. Not trying to dodge your question here, but I can see how this would play a significant role in each medication's relationship to one another - since none of these substances are purely taken by themselves in that regard.

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